EarlyDx Cloud

EarlyDx Cloud is a multimodal, cloud-based platform that integrates liquid biopsy and medical imaging to support noninvasive cancer detection. Designed for researchers, clinical laboratories, and biopharma partners, the platform combines genome-wide cfDNA methylation analysis with CT imaging to deliver automated data processing, AI-powered risk prediction, and reporting through a web interface.

The platform currently supports the assessment of indeterminate lung nodules (IPNs) by integrating MethylScan™ liquid biopsy results with chest CT imaging. The platform can be expanded for the detection of additional cancer types and clinical applications through the integration of multi-omics and imaging data.

Multi-Modal Data Integration

• MethylScan™ genome-wide cfDNA methylation sequencing
• DNA methylation array data
• User-provided multi-omics datasets.
• DICOM CT imaging
• Pubblic dataset, including NCI Cancer Research Data Commons (CRDC), for platform validation and co-analysis workflows.

Automated AI-Powered Analysis

EarlyDx Cloud automatically processes uploaded molecular and imaging data. For lung cancer applications, the platform performs image processing, lung and nodule segmentation, radiomics feature extraction, methylation analysis, and integrated malignancy risk prediction, generating comprehensive reports with minimal user intervention (Fig. 1).

Fig. 1. EarlyDx Cloud Multimodal Prediction Framework (MOEM)